Grote Konstanze, Stahlschmidt Beate, Talsness Chris E, Gericke Christine, Appel Klaus E, Chahoud Ibrahim
Institute of Clinical Pharmacology and Toxicology, Charité University Medical School, Campus Benjamin Franklin, 14195 Berlin, Germany.
Toxicology. 2004 Oct 1;202(3):145-58. doi: 10.1016/j.tox.2004.05.003.
Tributyltin (TBT) and triphenyltin (TPT) induce effects in male and female reproductive organs of rodents. They also cause tumors in these organs and it is theorized that they result from endocrine disruption. We studied the effects of 40 mg methyltestosterone (MTT), 0.5 or 15 mg TBT and 2, 6 or 12 mg TPT/kg bw on the male sexual development using a modification of the Rodent 20-Day Thyroid/Pubertal Male Assay. Male Wistar rats were treated per gavage for 30 days beginning at 23 days of age. A delay in the completion of preputial separation was observed after administration of MTT and 15 mg/kg TBT. Changes in weights of one or more reproductive organs were observed in all treatment groups. Testosterone concentration was decreased in the MTT, the 15 mg TBT as well as in the 6 and 12 mg TPT groups. A decrease in luteinizing hormone (LH) concentration was observed in the MTT and 15 mg TBT groups while an increase was seen after exposure to 6 mg TPT/kg bw. We conclude that peripubertal exposure to 15 mg TBT and 6 mg TPT/kg bw clearly affected male sexual development.
三丁基锡（TBT）和三苯基锡（TPT）会对啮齿动物的雄性和雌性生殖器官产生影响。它们还会导致这些器官出现肿瘤，据推测这是由内分泌干扰引起的。我们使用改良的啮齿动物20天甲状腺/青春期雄性试验，研究了40毫克甲基睾酮（MTT）、0.5或15毫克TBT以及2、6或12毫克TPT/千克体重对雄性性发育的影响。从23日龄开始，对雄性Wistar大鼠进行30天的灌胃治疗。在给予MTT和15毫克/千克TBT后，观察到包皮分离完成延迟。在所有治疗组中均观察到一个或多个生殖器官重量的变化。MTT组、15毫克TBT组以及6和12毫克TPT组的睾酮浓度均降低。在MTT组和15毫克TBT组中观察到促黄体生成素（LH）浓度降低，而在暴露于6毫克TPT/千克体重后则观察到LH浓度升高。我们得出结论，青春期前后暴露于15毫克TBT和6毫克TPT/千克体重会明显影响雄性性发育。
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