Pigolkin Iu I, Bogomolov D V, Bogomolova I N, Sergeeva L A
Arkh Patol. 2002 May-Jun;64(3):6-10.
Liver pathology in parenteral drug abusers (PDA) was studied morphometrically. Chronic hepatitis in PDA is characterized by high incidence of lymphoid follicles formation in the portal tracts and intralobularly, relatively low activity of portal hepatitis in significant expression of the lobular component of the inflammatory process, marked fibrosis and early formation of micronodular liver cirrhosis, noticeable proliferation of narrow bile ducts, high content of neutrophils, eosinophils, siderophages and common macrophages in the infiltrate and their granuloma-like accumulations in the portal tracts. These criteria are recommended for diagnosis of drug abuse by morphological data. The use of a morphometrical method is proposed for studying morphological manifestations of chronic hepatitis, for perfection of their classification, in particular.
对静脉药物滥用者(PDA)的肝脏病理进行了形态计量学研究。PDA中的慢性肝炎的特征是门管区和小叶内淋巴滤泡形成的发生率高,门脉性肝炎活动相对较低,炎症过程的小叶成分有明显表达,有明显纤维化和微结节性肝硬化的早期形成,小胆管明显增生,浸润物中中性粒细胞、嗜酸性粒细胞、含铁血黄素巨噬细胞和普通巨噬细胞含量高,且它们在门管区呈肉芽肿样聚集。建议根据形态学数据将这些标准用于药物滥用的诊断。尤其提出使用形态计量学方法来研究慢性肝炎的形态学表现,以完善其分类。