Tanashchiuk E L, Sekamova S M, Serov V V, Popova I V
Academician V. V. Serov's Group, I. M. Sechenov Moscow Medical Academy.
Arkh Patol. 2000 May-Jun;62(3):37-42.
69 patients with alcohol addiction infected with hepatitis viruses underwent clinical, laboratory and morphological examinations using light and electron microscopic studies of liver biopsies. Light microscopy revealed three variants of liver damage: viral, alcoholic and mixed. Both etiological factors affect manifestations and course of the disease as shown by electron microscopy in spite of morphological signs of only viral or mixed lesion. The lowest index of histological activity is found in combination alcohol + HCV, the highest index being in patients with HBV + HCV and HBV + HDV. Alcohol abuse in combination with HCV infection increases histological activity of liver damage.
69例感染肝炎病毒的酒精成瘾患者接受了临床、实验室及形态学检查，对肝活检组织进行了光镜和电镜研究。光镜检查发现肝损伤有三种类型：病毒性、酒精性和混合型。尽管电镜检查仅显示病毒或混合性病变的形态学特征，但两种病因学因素均影响疾病的表现和病程。组织学活性指数最低的是酒精 + HCV联合感染患者，最高的是HBV + HCV和HBV + HDV患者。酒精滥用与HCV感染共同作用会增加肝损伤的组织学活性。
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