Kayem Gilles, Davy Céline, Goffinet François, Thomas Carole, Clément Denis, Cabrol Dominique
Department of Obstetrics and Gynaecology, Maternité Port-Royal Hospital, Cochin APHP University René Descartes, Paris, France.
Obstet Gynecol. 2004 Sep;104(3):531-6. doi: 10.1097/01.AOG.0000136086.78099.0f.
To compare the impact of conservative and extirpative strategies for placenta accreta on maternal morbidity and mortality.
We retrospectively reviewed the medical records of all patients diagnosed with placenta accreta admitted to our tertiary center from January 1993 through December 2002. Two consecutive periods, A and B, were compared. During period A (January 1993 to June 1997), our written protocol called for the systematic manual removal of the placenta, to leave the uterine cavity empty. In period B (July 1997 to December 2002), we changed our policy by leaving the placenta in situ. The following outcomes over the 2 periods were compared: need for blood transfusion, hysterectomy, intensive care admission, duration of stay in intensive care, and postpartum endometritis.
Thirty-three cases of placenta accreta were observed among 31,921 deliveries (1.03/1,000). During period B, there was a reduction in the hysterectomy rate (from 11 [84.6%] to 3 [15%]; P <.001), the mean number of red blood cells transfused (3,230 +/- 2,170 mL versus 1,560 +/- 1,646 mL; P <.01), and disseminated intravascular coagulation (5 [38.5%] versus 1 [5.0%]; P =.02), compared with period A. There were 3 cases of sepsis in period B and none in period A (P =.26). At least 2 women with conservative management subsequently had successful pregnancies.
Leaving the placenta accreta in situ appears to be a safe alternative to removing the placenta.
比较胎盘植入的保守治疗策略和切除治疗策略对孕产妇发病率和死亡率的影响。
我们回顾性分析了1993年1月至2002年12月在我们三级医疗中心收治的所有诊断为胎盘植入患者的病历。比较了连续的两个时间段,即A段和B段。在A段(1993年1月至1997年6月),我们的书面方案要求系统地手动剥离胎盘,使子宫腔保持空虚。在B段(1997年7月至2002年12月),我们改变了策略,将胎盘留在原位。比较了这两个时间段的以下结果:输血需求、子宫切除术、重症监护病房收治情况、在重症监护病房的住院时间以及产后子宫内膜炎。
在31921例分娩中观察到33例胎盘植入(1.03/1000)。与A段相比,B段子宫切除率降低(从11例[84.6%]降至3例[15%];P<.001),平均红细胞输注量减少(3230±2170ml对1560±1646ml;P<.01),弥散性血管内凝血发生率降低(5例[38.5%]对1例[5.0%];P=.02)。B段有3例败血症,A段无(P=.26)。至少2例接受保守治疗的女性随后成功怀孕。
将胎盘植入留在原位似乎是一种安全的替代胎盘切除的方法。