Kohno Takeyuki, Tsuji Takumi, Hirayama Kaori, Watabe Kazuhito, Matsumoto Akiko, Kohno Tomoko, Fujita Tetsuro
Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.
Biol Pharm Bull. 2004 Sep;27(9):1392-6. doi: 10.1248/bpb.27.1392.
Oral administration of a novel immunomodulator, FTY720 (0.1 mg/kg, once a week), completely prevented the spontaneous development of dermatitis in NC/Nga mice. It also strongly suppressed hyper IgE production in serum, as well as hypertrophy of the epidermis and the degranulation of granulocytes in the skin, all of which were observed in mice in which the dermatitis had become established. These results strongly suggest that FTY720 is a promising candidate for treatment of human atopic dermatitis.
口服一种新型免疫调节剂FTY720（0.1毫克/千克，每周一次）可完全预防NC/Nga小鼠自发性皮炎的发生。它还能强烈抑制血清中高IgE的产生，以及表皮肥大和皮肤中粒细胞的脱颗粒，而这些现象在已患皮炎的小鼠中均有观察到。这些结果有力地表明，FTY720是治疗人类特应性皮炎的一个有前景的候选药物。
