Ermolov A S, Tveritneva L F, Pakhomova G V, Tsarenko S V, Kudriashova N E, Sordia D G, Spiridonova T G
Khirurgiia (Mosk). 2004(8):41-5.
Acute erosive lesions of upper parts of gastrointestinal tract with bleeding aggravate severe burn trauma, postoperative period after extensive surgeries and is the often component of polyorganic insufficiency syndrome. Gastric secretion in patients with severe burn trauma and neurotrauma was studied. Decrease of gastric secretory function due to central paresis of gastrointestinal tract and reflux of bile into stomach was seen in majority of patients with neurotrauma and acute gastric ulcers. On the contrary, in patients with burn shock increase of acid-secretory function of stomach was revealed. Schemes of prophylaxis and treatment of acute ulcers were developed. They included antacid therapy (for patients with increased secretion), regulators of motor-evacuatory function of stomach and intestine (for patients with paresis), drugs increased regenerative properties of mucosa, early enteral nutrition with balanced mixtures. This treatment in combination with hemostatic therapy and cure of main disease permitted to reduce number of gastroduodenal bleedings and lethality in these patients.
上消化道急性糜烂性病变伴出血会加重严重烧伤创伤、大型手术后的术后情况，且常为多器官功能不全综合征的组成部分。对严重烧伤创伤和神经创伤患者的胃分泌情况进行了研究。多数神经创伤和急性胃溃疡患者出现因胃肠道中枢性麻痹及胆汁反流至胃导致的胃分泌功能下降。相反，在烧伤休克患者中发现胃的酸分泌功能增强。制定了急性溃疡的预防和治疗方案。这些方案包括抗酸治疗（针对分泌增加的患者）、胃肠运动排空功能调节剂（针对麻痹患者）、增强黏膜再生特性的药物、使用均衡混合物进行早期肠内营养。这种治疗与止血治疗及主要疾病的治愈相结合，能够减少这些患者胃十二指肠出血的数量及死亡率。
