[采用蛋白质印迹分析检测中国慢性疲劳综合征患者血浆中博尔纳病病毒-p24抗体]
[Detection of antibody against Borna disease virus-p24 in the plasma of Chinese patients with chronic fatigue syndrome by Western-blot analysis].
作者信息
Li Yong-jie, Wang De-xin, Zhang Feng-min, Liu Zhan-dong, Yang Ai-ying, Ykuta K
机构信息
Department of Neurology, Beijing Friendship Hospital, Beijing 100050, China.
出版信息
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2003 Dec;17(4):330-3.
OBJECTIVE
To evaluate the prevalence of infection with Borna disease virus (BDV) in Chinese patients with chronic fatigue syndrome (CFS) and control subjects, and to discuss the etiological association between CFS and infection with BDV.
METHODS
The CDC (1994) diagnostic criteria for CFS were used for case definition. Sixty-one patients suffered from CFS were from 11 Provinces in China. To detect the antibody against BDV-p24 on the plasma samples from all cases and 73 healthy control subjects by Western-blotting analysis.
RESULTS
7 of the sixty-one cases and 0 of the controls were sero-positive for BDV-p24 antibody, there was a statistical significant difference between the two groups (11.48% vs 0%; P less than 0.010).
CONCLUSION
Chinese patients with CFS showed sero-positive identifying BDV infection, by comparison, anti.BDV-p24 antibody prevalence in patients was significantly higher than in controls. An etiological association may exist between CFS and BDV infection.
目的
评估中国慢性疲劳综合征（CFS）患者及对照人群中博尔纳病病毒（BDV）感染的患病率，并探讨CFS与BDV感染之间的病因学关联。
方法
采用美国疾病控制与预防中心（1994年）的CFS诊断标准进行病例定义。61例CFS患者来自中国11个省份。通过蛋白质免疫印迹分析检测所有病例及73名健康对照者血浆样本中抗BDV-p24抗体。
结果
61例病例中有7例BDV-p24抗体血清学呈阳性，对照者中无阳性，两组间差异有统计学意义（11.48% 对0%；P<0.010）。
结论
中国CFS患者显示出BDV感染血清学阳性，相比之下，患者中抗BDV-p24抗体患病率显著高于对照者。CFS与BDV感染之间可能存在病因学关联。
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