[T细胞淋巴瘤中EB病毒的检测及临床病理分析]

[Detection of Epstein-Barr virus in T cell lymphoma and clinicopathologic analysis].

作者信息

He Zu-gen, Huang Yan-ping, Guo Xiu-chan, Lin Dong-mei, Zeng Yi

机构信息

Department of Pathology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, China.

出版信息

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2003 Sep;17(3):229-33.

PMID:15340564

Abstract

BACKGROUND

To study the relationship of Epstein-Barr virus (EBV) and T cell lymphoma.

METHODS

Sixty cases of T cell lymphomas were examined for the presence of EBV using in situ hybridization for EBV encoded RNA (EBERs).

RESULTS

EBERs were detected in tumor cells in 37(69.8%) of 53 cases with peripheral T cell lymphoma, but in none of seven cases of precursor T lymphoblastic lymphoma. The total detected EBERs were 37(61.6%) in 60 cases of T cell lymphomas. By Revised European-American Lymphoma(REAL) classification, EBERs were detected in 2/2 angioimmuno-blastic T cell lymphoma,17/18 angiocentric lymphoma, 4/6 anaplastic large cell lymphoma and 14/27 peripheral T cell lymphoma, unspecified (51.9%). The frequency of EBERs among the extranodal peripheral T cell lymphoma was higher than the nodal (P less than 0.01) there was no significant correlation with the sex, age and clinical stage.

CONCLUSIONS

This study indicated that high incidence of EBV was observed in peripheral T cell lymphoma, with predilection for angiocentric lymphoma and extranodal presentation.

摘要

背景

研究爱泼斯坦-巴尔病毒（EBV）与T细胞淋巴瘤的关系。

方法

采用EBV编码RNA（EBERs）原位杂交技术检测60例T细胞淋巴瘤中EBV的存在情况。

结果

53例外周T细胞淋巴瘤中有37例（69.8%）肿瘤细胞检测到EBERs，而7例前体T淋巴母细胞淋巴瘤中均未检测到。60例T细胞淋巴瘤中总共检测到EBERs的有37例（61.6%）。按照欧美淋巴瘤修订分类（REAL），血管免疫母细胞性T细胞淋巴瘤2例中有2例检测到EBERs，血管中心性淋巴瘤18例中有17例，间变性大细胞淋巴瘤6例中有4例，未特指的外周T细胞淋巴瘤27例中有14例（51.9%）。结外外周T细胞淋巴瘤中EBERs的检出频率高于结内（P<0.01），与性别、年龄及临床分期无明显相关性。