[人杯状病毒引起的急性腹泻暴发调查]
[Investigation of an outbreak of acute diarrhea caused by Human calicivirus].
作者信息
Li Wen-zhang, Xie Hua-ping, Wu Hai-yan, Zhou Dao-yun, Zheng Li-shu, Cai Yun-shan, Kang You-ling, Jiang Xi, Fang Zhao-yin
机构信息
Guangan Hygiene and Antiepidemic Station, Sichuan Province, Guangan 638000, China.
出版信息
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2003 Sep;17(3):251-3.
BACKGROUND
To survey a diarrhea outbreak in Guangan city and analyze the cause of the disease.
METHODS
The population enrolled in the surveillance came from four different settings and was randomly sampled. Stool specimens collected from diarrhea patients were tested ordinarily for enteric bacteria and further examined for viral pathogens with PAGE, ELISA and RT-PCR.
RESULTS
In total, 4,567 persons were surveyed, among them 942 had acute diarrhea (prevalence 20.63%). The incidence was higher in rural area (28.6%) than in urban area (19.6%) (chi-square =22.29, P less than 0.005) with a peak in May 10 through 25 four human caliciviruses were detected from stool specimens by ELISA and RT-PCR in specimens from 4 and 1 patients, respectively.
CONCLUSION
Human calicivirus probably was the cause of this diarrhea outbreak in Guangan city.
背景
调查广安市一起腹泻暴发疫情并分析病因。
方法
监测人群来自四个不同场所，采用随机抽样。对腹泻患者采集的粪便标本常规检测肠道细菌，并进一步采用聚丙烯酰胺凝胶电泳（PAGE）、酶联免疫吸附测定（ELISA）和逆转录聚合酶链反应（RT-PCR）检测病毒病原体。
结果
共调查4567人，其中942人患急性腹泻（患病率20.63%）。农村地区发病率（28.6%）高于城市地区（19.6%）（卡方=22.29，P<0.005），5月10日至25日出现发病高峰。分别在4例和1例患者的粪便标本中通过ELISA和RT-PCR检测到4种人杯状病毒。
结论
人杯状病毒可能是广安市此次腹泻暴发的病因。
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