镜像抑制剂：L-DMDP，一种比对映体天然产物DMDP更有效、更具特异性的α-葡萄糖苷酶抑制剂。
Looking glass inhibitors: L-DMDP, a more potent and specific inhibitor of alpha-glucosidases than the enantiomeric natural product DMDP.
作者信息
Yu Chu-Yi, Asano Naoki, Ikeda Kyoko, Wang Mei-Xiang, Butters Terry D, Wormald Mark R, Dwek Raymond A, Winters Ana L, Nash Robert J, Fleet George W J
机构信息
Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, UK OX1 3TA.
出版信息
Chem Commun (Camb). 2004 Sep 7(17):1936-7. doi: 10.1039/b406035k. Epub 2004 Jul 29.
L-DMDP, prepared from D-gulonolactone, is a highly specific inhibitor of a number of plant and mammalian alpha-glucosidases [between 2 and 4 orders of magnitude more potent than the enantiomeric natural product DMDP] but is not an inhibitor of bacterial and yeast alpha-glucosidases. Additionally N-butyl-DMDP is a potent inhibitor of ceramide-specific glucosyltransferase but N-butyl-L-DMDP shows no inhibition.
由D-古洛糖酸内酯制备的L-DMDP是多种植物和哺乳动物α-葡萄糖苷酶的高度特异性抑制剂[比对映体天然产物DMDP的效力高2至4个数量级]，但不是细菌和酵母α-葡萄糖苷酶的抑制剂。此外，N-丁基-DMDP是神经酰胺特异性葡萄糖基转移酶的有效抑制剂，但N-丁基-L-DMDP没有抑制作用。
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