通过酰化/迈克尔加成反应联合进行的单酶两步一锅法合成含葡萄糖支链的N-取代咪唑衍生物。
A single-enzyme, two-step, one-pot synthesis of N-substituted imidazole derivatives containing a glucose branch via combined acylation/Michael addition reaction.
作者信息
Yao Shi-Ping, Lu De-Shui, Wu Qi, Cai Ying, Xu Shan-Hao, Lin Xian-Fu
机构信息
Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China.
出版信息
Chem Commun (Camb). 2004 Sep 7(17):2006-7. doi: 10.1039/b405796a. Epub 2004 Jul 29.
DOI:10.1039/b405796a
PMID:15340644
Abstract
Combined regioselective acylation/Michael addition reaction catalyzed by alkaline protease from Bacillus subtilis in anhydrous pyridine for synthesis of N-substituted imidazole derivatives containing a glucose branch via a novel single-enzyme, two-step, one-pot procedure is reported.
摘要
报道了在无水吡啶中，由枯草芽孢杆菌碱性蛋白酶催化的区域选择性酰化/迈克尔加成反应，通过一种新型的单酶、两步、一锅法合成含葡萄糖支链的N-取代咪唑衍生物。
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