Morrica Patrizia, Fidente Paola, Seccia Serenella
Dipartimento di Chimica Farmaceutica e Tossicologica, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
Biomed Chromatogr. 2004 Sep;18(7):450-6. doi: 10.1002/bmc.335.
Photolysis of imazosulfuron was studied in aqueous solution under UV light. The reaction followed a pseudo-first-order kinetic with significant correlation coefficient. The major photodegradation products of imazosulfuron after irradiation under UV light were separated and tentatively identified by HPLC-MS analysis as (4,6-dimethoxypyrimidine-2-yl)aminocarbonylsulfamic acid, 4,6-dimethoxy-2-ureidopyrimidine and 2,2'-dichloro-[3,3'] bi [imidazo[1,2-a] pyridinyl]. The results indicate that different reaction pathways are followed: (1) cleavage of the sulfonylurea bridge; (2) desulfonylation, which can proceed either by a carbon-sulfur cleavage or a nitrogen-sulfur cleavage. A mechanism for the formation of the photoproducts is proposed.
在紫外光下研究了咪唑磺隆在水溶液中的光解作用。该反应遵循具有显著相关系数的准一级动力学。咪唑磺隆在紫外光照射后的主要光降解产物通过高效液相色谱-质谱分析进行分离，并初步鉴定为（4,6-二甲氧基嘧啶-2-基）氨基羰基氨基磺酸、4,6-二甲氧基-2-脲嘧啶和2,2'-二氯-[3,3']联[咪唑并[1,2-a]吡啶基]。结果表明，遵循不同的反应途径：（1）磺酰脲桥的断裂；（2）脱磺酰基作用，其可通过碳-硫断裂或氮-硫断裂进行。提出了光产物形成的机制。
