鼠疫耶尔森菌温度转变过程中基因表达的时间性全局变化。
Temporal global changes in gene expression during temperature transition in Yersinia pestis.
作者信息
Motin Vladimir L, Georgescu Anca M, Fitch Joseph P, Gu Pauline P, Nelson David O, Mabery Shalini L, Garnham Janine B, Sokhansanj Bahrad A, Ott Linda L, Coleman Matthew A, Elliott Jeffrey M, Kegelmeyer Laura M, Wyrobek Andrew J, Slezak Thomas R, Brubaker Robert R, Garcia Emilio
机构信息
Biology and Biotechnology Research Program, L-452, 7000 East Ave., Livermore, CA 94550, USA.
出版信息
J Bacteriol. 2004 Sep;186(18):6298-305. doi: 10.1128/JB.186.18.6298-6305.2004.
Abstract
DNA microarrays encompassing the entire genome of Yersinia pestis were used to characterize global regulatory changes during steady-state vegetative growth occurring after shift from 26 to 37 degrees C in the presence and absence of Ca2+. Transcriptional profiles revealed that 51, 4, and 13 respective genes and open reading frames (ORFs) on pCD, pPCP, and pMT were thermoinduced and that the majority of these genes carried by pCD were downregulated by Ca2+. In contrast, Ca2+ had little effect on chromosomal genes and ORFs, of which 235 were thermally upregulated and 274 were thermally downregulated. The primary consequence of these regulatory events is profligate catabolism of numerous metabolites available in the mammalian host.
摘要
利用覆盖鼠疫耶尔森菌全基因组的DNA微阵列，对在26℃和37℃之间转换、有无Ca2+存在的情况下，稳态营养生长期间的全局调控变化进行表征。转录谱显示，pCD、pPCP和pMT上分别有51个、4个和13个基因及开放阅读框（ORF）被热诱导，且pCD携带的这些基因中的大多数被Ca2+下调。相比之下，Ca2+对染色体基因和ORF影响很小，其中235个被热上调，274个被热下调。这些调控事件的主要后果是对哺乳动物宿主中大量可用代谢物的过度分解代谢。
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