Cornelis Guy R
Biozentrum der Universität Basel, Klingelbergstr. 50-70, CH-4056 Basel, Switzerland.
Nat Rev Mol Cell Biol. 2002 Oct;3(10):742-52. doi: 10.1038/nrm932.
'Type III secretion'--the mechanism by which some pathogenic bacteria inject proteins straight into the cytosol of eukaryotic cells to 'anaesthetize' or 'enslave' them--was discovered in 1994. Important progress has been made in this area during the past few years: the bacterial organelles responsible for this secretion--called 'injectisomes'--have been visualized, the structures of some of the bacterial protein 'effectors' have been determined, and considerable progress has been made in understanding the intracellular action of the effectors. Type III secretion is key to the pathogenesis of bacteria from the Yersinia genus.
“III型分泌系统”——某些致病细菌将蛋白质直接注入真核细胞胞质溶胶以“麻醉”或“奴役”细胞的机制——于1994年被发现。在过去几年里，该领域取得了重要进展：负责这种分泌的细菌细胞器——称为“注射体”——已被可视化，一些细菌蛋白质“效应器”的结构已被确定，并且在理解效应器的细胞内作用方面取得了相当大的进展。III型分泌系统是耶尔森氏菌属细菌发病机制的关键。
