幼儿肠套叠：一项针对170万儿童的队列研究。
Intussusception in early childhood: a cohort study of 1.7 million children.
作者信息
Fischer Thea Kølsen, Bihrmann Kristine, Perch Michael, Koch Anders, Wohlfahrt Jan, Kåre Mølbak, Melbye Mads
机构信息
Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS-A34, Atlanta, GA 30333, USA.
出版信息
Pediatrics. 2004 Sep;114(3):782-5. doi: 10.1542/peds.2004-0390.
OBJECTIVE
To describe incidence and temporal trends of intussusceptions in Danish children during 1980 to 2001.
METHODS
A population-based cohort study was conducted of 1.67 million children who were younger than 5 years during 1980 to 2001 and were followed up for 6.66 million person-years. The Danish National Patient Registry was used to identify cases of intussusception in the cohort. Age-specific incidence rates were main outcome measure.
RESULTS
A total of 1814 cases of intussusception among children who were younger than 5 years were reported from 1980 to 2001. The incidence rate remained fairly constant during 1980 to 1990 but decreased by 55% (95% confidence interval: 43%-65%) from 1990 to 2001. The reduction was most pronounced among children aged 3 to 5 months.
CONCLUSIONS
The incidence of intussusception among Danish children declined significantly during the 1990s, particularly among infants 3 to 5 months of age.
目的
描述1980年至2001年丹麦儿童肠套叠的发病率及时间趋势。
方法
对1980年至2001年期间167万名5岁以下儿童进行了一项基于人群的队列研究，随访时间达666万人年。丹麦国家患者登记处用于确定队列中的肠套叠病例。特定年龄发病率是主要结局指标。
结果
1980年至2001年期间，共报告了1814例5岁以下儿童肠套叠病例。1980年至1990年期间发病率保持相当稳定，但从1990年至2001年下降了55%（95%置信区间：43%-65%）。这种下降在3至5个月大的儿童中最为明显。
结论
20世纪90年代丹麦儿童肠套叠发病率显著下降，尤其是在3至5个月大的婴儿中。
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