孕早期母血中胎儿DNA增加与子痫前期风险增加有关。

Increased fetal DNA in the maternal circulation in early pregnancy is associated with an increased risk of preeclampsia.

作者信息

Cotter Amanda M, Martin Cara M, O'leary John J, Daly Sean F

机构信息

Department of Pathology, Trinity College Dublin, Dublin, Ireland.

出版信息

Am J Obstet Gynecol. 2004 Aug;191(2):515-20. doi: 10.1016/j.ajog.2004.01.040.

DOI:10.1016/j.ajog.2004.01.040

PMID:15343229

Abstract

OBJECTIVE

The aim of our study was to determine if fetal DNA is present in the maternal circulation in early pregnancy before the clinical manifestation of preeclampsia, and if this could be predictive of the development of preeclampsia.

STUDY DESIGN

Blood were obtained from patients attending for a first antenatal visit. Cases were asymptomatic women who subsequently developed preeclampsia matched to control women for parity and gestational age. Real-time polymerase chain reaction (PCR) using TaqMan primers and probes directed against SRY gene sequences quantified fetal DNA in the maternal circulation.

RESULTS

There were 88 cases of women with preeclampsia and 176 control women, both sampled at a mean gestation (+/-SD) of 15.7 +/- 3.6 weeks. The presence of fetal DNA in the maternal circulation in early pregnancy is associated with an 8-fold increased risk of developing preeclampsia.

CONCLUSION

Increased fetal DNA is present in the maternal circulation in early pregnancy in women who subsequently develop pre-eclampsia and there appears to be a graded response between the quantity of fetal DNA and the risk of developing pre-eclampsia.

摘要