着色性干皮病中DNA修复复制缺陷。1968年。
Defective repair replication of DNA in xeroderma pigmentosum. 1968.
作者信息
Cleaver J E
机构信息
Laboratory of Radiobiology, University of California Medical Center, San Francisco, California, USA.
出版信息
DNA Repair (Amst). 2004 Feb 3;3(2):183-87.
PMID:15344228
Abstract
Most forms of the human hereditary disease xeroderma pigmentation (XP) are due to a defect in nucleotide excision repair of DNA damage in skin cells associated with exposure to sunlight. This discovery by James Cleaver had an important impact on our understanding of nucleotide excision repair in mammals.
摘要
人类遗传性疾病着色性干皮病（XP）的大多数类型是由于皮肤细胞中与阳光照射相关的DNA损伤的核苷酸切除修复缺陷所致。詹姆斯·克利弗的这一发现对我们理解哺乳动物中的核苷酸切除修复产生了重要影响。
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