Biggee Beth Anne, McAlindon Timothy
Tufts-New England Medical Center, Boston, MA 02111, USA.
Med Health R I. 2004 Jun;87(6):176-9.
Glucosamine is a popular nutritional supplement for OA. This supplement has shown moderate efficacy in meta-analysis and large industry-sponsored clinical trials. However, smaller independent studies have not shown significant benefit. It is difficult to compare these clinical trials due to heterogeneity in trial design, differences in glucosamine products, and differences in osteoarthritic populations being studied. The National Center for Complementary and Alternative Medicine and the National Institute of Arthritis and Musculoskeletal and Skin Disease (NIAMS/NCCAM) have funded a multicenter five arm placebo controlled study called The Glucosamine Arthritis Intervention Trial (GAIT). GAIT spans 24 weeks, enrolling 1588 subjects, at 13 centers comparing the efficacy of glucosamine sulfate, chondroitin sulfate, glucosamine with chondroitin, to placebo and compared to celecoxib for knee OA. This study may have final data in March 2005.
氨基葡萄糖是骨关节炎常用的营养补充剂。在荟萃分析和大型企业资助的临床试验中，这种补充剂已显示出一定疗效。然而，规模较小的独立研究并未显示出显著益处。由于试验设计的异质性、氨基葡萄糖产品的差异以及所研究的骨关节炎人群的差异，很难对这些临床试验进行比较。美国国立补充与替代医学中心和美国国立关节炎、肌肉骨骼和皮肤病研究所（NIAMS/NCCAM）资助了一项名为氨基葡萄糖关节炎干预试验（GAIT）的多中心、五组、安慰剂对照研究。GAIT为期24周，在13个中心招募了1588名受试者，比较硫酸氨基葡萄糖、硫酸软骨素、氨基葡萄糖与软骨素联合使用与安慰剂的疗效，并与塞来昔布治疗膝骨关节炎的疗效进行比较。这项研究可能会在2005年3月得出最终数据。
