Batra A, Tripathi R P, Singh A K
NMR Research Centre, Institute Of Nuclear Medicine and Allied Sciences, Defence Research and Development Organization, SK Mazumdar Road, Timarpur, Delhi-110054, India.
Australas Radiol. 2004 Sep;48(3):324-32. doi: 10.1111/j.0004-8461.2004.01315.x.
The purpose of the present paper was to evaluate the utility of perfusion MRI in cerebral gliomas showing imperceptible contrast enhancement on conventional MRI, and to evaluate the relationships of perfusion MRI and magnetic resonance (MR) spectroscopic results in these tumours. Twenty-two patients with histopathologically proven cerebral gliomas and showing insignificant contrast enhancement on conventional MR were included in the present study. All patients underwent perfusion MRI and MR spectroscopy on a 1.5-T MR system. Significant differences of the relative cerebral blood volume (rCBV) values and the choline : creatine ratios were noted between low-grade and anaplastic gliomas (P < 0.01). Good correlation was found between the rCBV values and the choline : creatine values (y = 0. 532x + 1.5643; r = 0.67). Perfusion MRI can be a useful tool in assessing the histopathological grade of non-contrast-enhancing cerebral gliomas. Along with MR spectroscopic imaging it can serve as an important technique for preoperative characterization of such gliomas, so that accurate targeting by stereotactic biopsies is possible.
本文的目的是评估灌注磁共振成像（MRI）在常规MRI上显示无明显对比增强的脑胶质瘤中的应用价值，并评估这些肿瘤中灌注MRI与磁共振（MR）波谱结果之间的关系。本研究纳入了22例经组织病理学证实的脑胶质瘤患者，这些患者在常规MR上显示无明显对比增强。所有患者均在1.5-T MR系统上接受了灌注MRI和MR波谱检查。低级别胶质瘤和间变性胶质瘤之间的相对脑血容量（rCBV）值及胆碱与肌酸比值存在显著差异（P < 0.01）。rCBV值与胆碱与肌酸值之间存在良好的相关性（y = 0. 532x + 1.5643；r = 0.67）。灌注MRI可作为评估无对比增强脑胶质瘤组织病理学分级的有用工具。与MR波谱成像一起，它可作为术前对此类胶质瘤进行特征性描述的重要技术，从而使立体定向活检能够进行准确靶向。
