Ellis P M, Delaney G, Della-Fiorentina S, Moylan E
Department of Medical Oncology, Liverpool Hospital, Sydney, New South Wales, Australia.
Australas Radiol. 2004 Sep;48(3):364-70. doi: 10.1111/j.0004-8461.2004.01320.x.
The purpose of the present paper was to review the outcomes of care of small cell lung cancer (SCLC) at one Sydney teaching hospital. A retrospective cohort study was carried out of patients with SCLC seen between January 1996 and July 2000. The main outcomes were relapse-free and overall survival. Secondary outcomes of interest were the uniformity of staging investigations, initial treatment, use of prophylactic cranial irradiation (PCI), patterns of relapse and treatment received following relapse. One hundred and three patients with SCLC were treated at the Liverpool Hospital Cancer Therapy Centre during this period. There were 58 men (56%) and 45 women (44%). Forty-two patients (41%) had limited stage disease (LD) and 61 (59%) had extensive stage disease (ED). There was considerable variation in staging investigations. There was little variation in systemic treatment of SCLC. Only 32 of 42 patients with limited stage SCLC were candidates for thoracic radiotherapy and only seven patients received PCI. Median relapse-free survival was 11.2 months (95% confidence interval (CI): 7.7-14.8) for patients with LD and 6 months (95%CI: 4.4-7.5) for ED. Median overall survival was 15.1 months (95%CI: 11-19.1) for patients with LD and 8.9 months (95%CI: 7.5-10.2) for ED. Some health outcomes similar to that reported in clinical trials can be achieved in clinical practice. Measuring health outcomes is an important process of maintaining quality of care.
本文旨在回顾悉尼一家教学医院对小细胞肺癌(SCLC)的护理结果。对1996年1月至2000年7月间诊治的SCLC患者进行了一项回顾性队列研究。主要结局是无复发生存期和总生存期。感兴趣的次要结局包括分期检查的一致性、初始治疗、预防性颅脑照射(PCI)的使用、复发模式以及复发后的治疗情况。在此期间,利物浦医院癌症治疗中心共治疗了103例SCLC患者。其中男性58例(56%),女性45例(44%)。42例患者(41%)为局限期疾病(LD),61例(59%)为广泛期疾病(ED)。分期检查存在较大差异。SCLC的全身治疗差异不大。42例局限期SCLC患者中只有32例适合接受胸部放疗,只有7例患者接受了PCI。LD患者的中位无复发生存期为11.2个月(95%置信区间(CI):7.7 - 14.8),ED患者为6个月(95%CI:4.4 - 7.5)。LD患者的中位总生存期为15.1个月(95%CI:11 - 19.1),ED患者为8.9个月(95%CI:7.5 - 10.2)。在临床实践中可以实现一些与临床试验报告相似的健康结局。衡量健康结局是维持医疗质量的重要过程。