Borg M F
Department of Radiation Oncology, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia.
Australas Radiol. 2004 Sep;48(3):376-82. doi: 10.1111/j.0004-8461.2004.01322.x.
Higher local recurrence rates have been reported in young women with invasive carcinoma of the breast treated with breast-conserving therapy (BCT). However, age itself may not be responsible for this increased risk of recurrence. To investigate this further, a computerized literature search of MEDLINE was performed using data from 1996 to May 2003. The research was limited to female patients with localized, invasive adenocarcinoma of the breast but also included patients of young age with ductal carcinoma in situ. Women of young age with breast cancer, treated with BCT are at an increased risk of recurrence ranging from 7.5 to 35%. However, the data would suggest that the increased risk is secondary to the association of young age with more aggressive tumours and a positive family history of breast cancer. Other factors that may explain the adverse prognosis in women of a young age include associated genetic abnormalities and the lack of mammographic screening programmes for women of young age. Young age is a risk factor for breast recurrence after BCT. However, management decisions should be based on tumour stage, grade and other related prognostic features rather than on young age alone.
据报道，接受保乳治疗（BCT）的年轻女性浸润性乳腺癌局部复发率较高。然而，年龄本身可能并非导致这种复发风险增加的原因。为进一步研究这一问题，利用1996年至2003年5月的数据对MEDLINE进行了计算机文献检索。该研究仅限于患有局限性浸润性腺癌的女性患者，但也包括患有导管原位癌的年轻患者。接受BCT治疗的年轻乳腺癌女性复发风险增加，范围在7.5%至35%之间。然而，数据表明，风险增加是由于年轻与更具侵袭性的肿瘤以及乳腺癌家族史阳性相关。其他可能解释年轻女性预后不良的因素包括相关的基因异常以及缺乏针对年轻女性的乳腺钼靶筛查项目。年轻是BCT后乳腺复发的一个风险因素。然而，治疗决策应基于肿瘤分期、分级和其他相关的预后特征，而不是仅仅基于年龄。
