皮肤γδ T细胞——在胸腺中选择目的地并寻求指引
Cutaneous gammadelta T cells-selecting a destination and asking for directions in the thymus.
作者信息
Campbell Daniel J
机构信息
Benaroya Research Institute at Virginia Mason, 1201 9th Avenue, Seattle, WA 98101, USA.
出版信息
Immunity. 2004 Jul;21(1):4-5. doi: 10.1016/j.immuni.2004.07.002.
PMID:15345215
Abstract
T cell receptor-defined subsets of gammadelta T cells differentially localize in cutaneous, intestinal, or reproductive epithelium. In this issue of Immunity, Xiong et al. show that murine Vgamma3+ T cells undergo TCR-dependent selection in the fetal thymus that drives expression of a cutaneous homing receptor.
摘要
由T细胞受体定义的γδ T细胞亚群在皮肤、肠道或生殖上皮中存在差异定位。在本期《免疫》杂志中，熊等人表明，小鼠Vγ3 + T细胞在胎儿胸腺中经历了TCR依赖性选择，从而驱动皮肤归巢受体的表达。
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