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1-[4-(Methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole derivatives.

作者信息

Charlier Caroline, Norberg Bernadette, Goossens Laurence, Hénichart Jean Pierre, Durant François

机构信息

Lab. Chimie Moléculaire Structurale, Facultés Universitaires N.-D. de la Paix, 61 Rue de Bruxelles, B-5000 Namur, Belgium.

出版信息

Acta Crystallogr C. 2004 Sep;60(Pt 9):o648-52. doi: 10.1107/S0108270104016117. Epub 2004 Aug 11.

DOI:10.1107/S0108270104016117
PMID:15345845
Abstract

Three related compounds containing a pyrazole moiety with vicinal phenyl rings featuring a methylsulfonyl substituent are described, namely 3-methyl-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole, C17H16N2O2S, ethyl 1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole-3-carboxylate, C19H18N2O4S, and 1-[4-(methylsulfonyl)phenyl]-3-[3-(morpholino)phenoxymethyl]-5-phenyl-1H-pyrazole, C27H27N3O4S. The design of these compounds was based on celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, in order to study the influence of various substituents on COX-2 and 5-lipoxygenase (5-LOX) inhibition.

摘要

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