4-和5-雄甾烯的构效关系：3β-乙酰氧基-17-甲基-17-氧代-16,17-开环-5-雄甾烯-16-腈和17-甲基-3,17-二氧代-16,17-开环-4-雄甾烯-16-腈
Structure-activity relationships in 4- and 5-androstene: 3beta-acetoxy-17-methyl-17-oxo-16,17-seco-5-androstene-16-carbonitrile and 17-methyl-3,17-dioxo-16,17-seco-4-androstene-16-carbonitrile.
作者信息
Lazar Dusan, Klisurić Olivera, Stanković Slobodanka, Penov-Gasi Katarina, Djurendić Evgenija, Kovacević Radmila
机构信息
Department of Physics, University of Novi Sad, Trg Dositeja Obradovića 4, 21000 Novi Sad, Serbia and Montenegro.
出版信息
Acta Crystallogr C. 2004 Sep;60(Pt 9):o671-3. doi: 10.1107/S0108270104017457. Epub 2004 Aug 11.
The title compounds, C22H31NO3 and C20H27NO2, have similar conformations except in the molecular geometry and the bonding of two of the rings. These differences lead to marked differences in the biological activities of these compounds. Molecules of both compounds are linked by weak C-H...O hydrogen bonds in the crystal structures.
标题化合物C22H31NO3和C20H27NO2具有相似的构象，只是在分子几何形状和两个环的键合方面有所不同。这些差异导致这些化合物的生物活性存在显著差异。在晶体结构中，两种化合物的分子均通过弱C-H...O氢键相连。
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