唐氏综合征患儿血清IgG亚类模式异常。
Abnormal serum IgG subclass pattern in children with Down's syndrome.
作者信息
Annerén G, Magnusson C G, Lilja G, Nordvall S L
机构信息
Department of Clinical Genetics, University Hospital, Uppsala, Sweden.
出版信息
Arch Dis Child. 1992 May;67(5):628-31. doi: 10.1136/adc.67.5.628.
Susceptibility to infections is a well known feature of Down's syndrome. The possible relation between this predisposition and the serum concentrations of the IgG subclasses was studied in 38 children with Down's syndrome aged 1-12 years. An age matched group of 50 healthy children served as controls. The serum concentrations of IgG1 and IgG3 were significantly raised among children with Down's syndrome in all three age groups studied (that is 1-2.5, 4-8, and 9-12 years). The serum concentrations of IgG2 were normal in the first two groups but significantly reduced in the third age group. In contrast, the concentrations of IgG4 among children with Down's syndrome were significantly reduced in all three age groups. Moreover, among the children with Down's syndrome aged 4-12 years 68% (15/22) had IgG4 concentrations below 2 SDs of the geometrical mean of the controls. The results may partially explain the proneness of children with Down's syndrome to infections with encapsulated bacteria. Although the underlying cause of these abnormalities is unknown, IgG subclass determination seems relevant in the clinical evaluation of children with Down's syndrome.
易感染是唐氏综合征的一个众所周知的特征。在38名年龄在1至12岁的唐氏综合征患儿中，研究了这种易感性与IgG亚类血清浓度之间的可能关系。将50名年龄匹配的健康儿童作为对照组。在所研究的所有三个年龄组（即1至2.5岁、4至8岁和9至12岁）的唐氏综合征患儿中，IgG1和IgG3的血清浓度均显著升高。在前两组中，IgG2的血清浓度正常，但在第三年龄组中显著降低。相比之下，在所有三个年龄组的唐氏综合征患儿中，IgG4的浓度均显著降低。此外，在4至12岁的唐氏综合征患儿中，68%（15/22）的IgG4浓度低于对照组几何平均数的2个标准差。这些结果可能部分解释了唐氏综合征患儿易感染包膜细菌的倾向。尽管这些异常的根本原因尚不清楚，但IgG亚类测定在唐氏综合征患儿的临床评估中似乎具有相关性。
Zotero 插件