Annerén G, Magnusson C G, Nordvall S L
Department of Clinical Genetics, University Hospital, Uppsala, Sweden.
Arch Dis Child. 1990 Dec;65(12):1353-5. doi: 10.1136/adc.65.12.1353.
In a previous study on children with Down's syndrome a reduced rate of infections was reported by their parents after the children had received six months' treatment with selenium supplements. In the present study the concentrations of the four IgG subclasses were measured in 29 of these children in samples of serum obtained before and immediately after the period of supplementation and one year after it had finished. Selenium had a significant augmentative effect on the serum concentrations of IgG2 and IgG4, but not of IgG1 and IgG3. This effect was not related to age, as among children over the age of 6 years the serum concentrations of IgG2 and IgG4 had decreased significantly one year after the treatment had been stopped. This study suggests that selenium has an immunoregulatory effect, which might be of importance in both basic research and clinical practice.
在之前一项针对唐氏综合征患儿的研究中，患儿父母报告称，在患儿接受了为期六个月的硒补充剂治疗后，感染率有所降低。在本研究中，对其中29名患儿在补充期之前、刚结束补充期时以及结束一年后的血清样本中四种IgG亚类的浓度进行了测量。硒对IgG2和IgG4的血清浓度有显著的增强作用，但对IgG1和IgG3没有影响。这种作用与年龄无关，因为在6岁以上的儿童中，治疗停止一年后，IgG2和IgG4的血清浓度显著下降。本研究表明，硒具有免疫调节作用，这在基础研究和临床实践中可能都很重要。
