Kamitakahara M, Kawashita M, Miyata N, Kokubo T, Nakamura T
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
J Mater Sci Mater Med. 2002 Nov;13(11):1015-20. doi: 10.1023/a:1020324101682.
Polydimethylsiloxane (PDMS)-CaO-SiO(2) hybrids with starting compositions containing PDMS/(Si(OC(2)H(5))(4)+PDMS) weight ratio=0.30, H(2)O/Si(OC(2)H(5))(4) molar ratio=2, and Ca(NO(3))(2)/Si(OC(2)H(5))(4) molar ratios=0-0.2, were prepared by the sol-gel method. The apatite-forming ability of the hybrids increased with increasing calcium content in the Ca(NO(3))(2)/Si(OC(2)H(5))(4) molar ratio range 0-0.1. The hybrids with a Ca(NO(3))(2)/Si(OC(2)H(5))(4) molar ratio range 0.1-0.2 formed apatite on their surfaces in a simulated body fluid (SBF) within 12 h. The hybrid with a Ca(NO(3))(2)/Si(OC(2)H(5))(4) molar ratio of 0.10 showed an excellent apatite-forming ability in SBF with a low release of silicon into SBF. It also showed mechanical properties analogous to those of human cancellous bones. This hybrid is expected to be useful as a new type of bioactive material.
通过溶胶 - 凝胶法制备了起始组成中聚二甲基硅氧烷（PDMS）/(四乙氧基硅烷（Si(OC₂H₅)₄）+ PDMS)重量比 = 0.30、水/四乙氧基硅烷（Si(OC₂H₅)₄）摩尔比 = 2以及硝酸钙（Ca(NO₃)₂）/四乙氧基硅烷（Si(OC₂H₅)₄）摩尔比 = 0 - 0.2的聚二甲基硅氧烷（PDMS）-氧化钙（CaO）-二氧化硅（SiO₂）杂化材料。在硝酸钙（Ca(NO₃)₂）/四乙氧基硅烷（Si(OC₂H₅)₄）摩尔比范围为0 - 0.1时，杂化材料的磷灰石形成能力随钙含量的增加而增强。硝酸钙（Ca(NO₃)₂）/四乙氧基硅烷（Si(OC₂H₅)₄）摩尔比范围为0.1 - 0.2的杂化材料在模拟体液（SBF）中12小时内其表面形成了磷灰石。硝酸钙（Ca(NO₃)₂）/四乙氧基硅烷（Si(OC₂H₅)₄）摩尔比为0.10的杂化材料在SBF中表现出优异的磷灰石形成能力，且硅向SBF中的释放量较低。它还表现出与人类松质骨类似的力学性能。这种杂化材料有望作为一种新型生物活性材料发挥作用。
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