Miyata Noboru, Fuke Ken-ichi, Chen Qi, Kawashita Masakazu, Kokubo Tadashi, Nakamura Takashi
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Sakyo-ku, Kyoto, 606-8501, Japan.
Biomaterials. 2004 Jan;25(1):1-7. doi: 10.1016/s0142-9612(03)00463-0.
Hydrolysis and polycondensation of triethoxysilane end-capped Poly (tetramethylene oxide) (Si-PTMO), tetraethoxysilane (TEOS), tetraisopropyltitanate (TiPT) and calcium nitrate (Ca(NO(3))(2)) gave transparent monolithics of PTMO-modified CaO-SiO(2)-TiO(2) hybrids. The samples with (TiPT)/(TEOS+TiPT) molar ratios from 0 to 0.20 under constant ratio of (Si-PTMO)/(TEOS+TiPT) of 2/3 in weight were prepared. It was found that the incorporation of TiO(2) component into a PTMO-CaO-SiO(2) hybrid results in an increase in the apatite-forming ability in a simulated body fluid: the hybrids with (TiPT)/(TEOS+TiPT) of 0.10 and 0.20 in mol formed an apatite on their surfaces within only 0.5 day. It seemed that, within the range of compositions studied, the TiO(2) content little affects the overall mechanical properties: Young's modulus were 52-55MPa, tensile strength, 7-9MPa, and strain at failure, about 30%. Thus, the organic-inorganic hybrids exhibiting both fairly high apatite-forming ability and high capability for deformation were obtained. These hybrid materials may be useful as new kind of bioactive bone-repairing materials.
三乙氧基硅烷封端的聚四亚甲基醚二醇（Si-PTMO）、四乙氧基硅烷（TEOS）、四异丙醇钛（TiPT）和硝酸钙（Ca(NO₃)₂）的水解和缩聚反应生成了PTMO改性的CaO-SiO₂-TiO₂杂化透明整体材料。制备了在（Si-PTMO）/（TEOS+TiPT）重量比为2/3恒定的情况下，（TiPT）/（TEOS+TiPT）摩尔比从0到0.20的样品。研究发现，将TiO₂组分引入PTMO-CaO-SiO₂杂化材料中会导致在模拟体液中磷灰石形成能力的提高：（TiPT）/（TEOS+TiPT）摩尔比为0.10和0.20的杂化材料在其表面仅在0.5天内就形成了磷灰石。在研究的组成范围内，TiO₂含量似乎对整体力学性能影响很小：杨氏模量为52-55MPa，拉伸强度为7-9MPa，断裂应变约为30%。因此，获得了兼具相当高的磷灰石形成能力和高变形能力的有机-无机杂化材料。这些杂化材料可能作为新型生物活性骨修复材料有用。
