Bian Xiu Wu, Chen Jian Hong, Jiang Xue Feng, Bai Jia Si, Wang Qing Liang, Zhang Xia
Institute of Pathology, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR of China.
Int Immunopharmacol. 2004 Nov;4(12):1537-47. doi: 10.1016/j.intimp.2004.07.017.
Many pathological processes including wound healing, chronic inflammation and cancer require angiogenesis, i.e., the formation of new vasculature in the lesions. Accumulating evidence indicates that angiogenesis is crucial for both chronic inflammation and the growth of malignant tumors with the participation of diverse cytokines, chemokines and growth factors. It is nevertheless believed that differences exist in angiogenesis between cancer and chronic inflammatory diseases. The aim of this review is to outline the characteristics of angiogenesis in chronic inflammation and cancer. A better understanding of the angiogenic processes may facilitate the design of more effective therapies for chronic inflammation and cancer.
许多病理过程，包括伤口愈合、慢性炎症和癌症，都需要血管生成，即在病变部位形成新的脉管系统。越来越多的证据表明，血管生成在多种细胞因子、趋化因子和生长因子的参与下，对慢性炎症和恶性肿瘤的生长都至关重要。然而，人们认为癌症和慢性炎症性疾病在血管生成方面存在差异。本综述的目的是概述慢性炎症和癌症中血管生成的特征。更好地理解血管生成过程可能有助于设计出针对慢性炎症和癌症更有效的治疗方法。
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