Maruotti Nicola, Annese Tiziana, Cantatore Francesco Paolo, Ribatti Domenico
Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Piazza Giulio Cesare, 11, Policlinico, 70124, Bari, Italy.
Vasc Cell. 2013 Jun 1;5(1):11. doi: 10.1186/2045-824X-5-11.
Angiogenesis plays a key role in several rheumatic diseases, including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, systemic sclerosis, systemic lupus erythematosus, and vasculitides. An imbalance between angiogenic inducers and inhibitors seems to be a critical factor in pathogenesis of these diseases. Macrophages promote angiogenesis during rheumatoid arthritis. In addition, macrophages can produce a variety of pro-angiogenic factors that have been associated with the angiogenic response occurring during other rheumatic diseases. Lastly, macrophages could be a target in the treatment of rheumatoid arthritis and other rheumatic diseases. Nevertheless, further studies are needed to better elucidate the exact role of macrophage in angiogenesis in these diseases.
血管生成在多种风湿性疾病中起关键作用，包括类风湿性关节炎、骨关节炎、强直性脊柱炎、系统性硬化症、系统性红斑狼疮和血管炎。血管生成诱导剂和抑制剂之间的失衡似乎是这些疾病发病机制中的一个关键因素。巨噬细胞在类风湿性关节炎期间促进血管生成。此外，巨噬细胞可产生多种促血管生成因子，这些因子与其他风湿性疾病期间发生的血管生成反应有关。最后，巨噬细胞可能是类风湿性关节炎和其他风湿性疾病治疗的靶点。然而，需要进一步研究以更好地阐明巨噬细胞在这些疾病血管生成中的确切作用。
