Yildiz N, Yildiz S, Ertekin C, Aydoğdu I, Uludag B
Department of Clinical Neurophysiology, Ege University, Medical School Hospital, Izmir, Turkey.
Clin Neurophysiol. 2004 Oct;115(10):2343-9. doi: 10.1016/j.clinph.2004.04.021.
To determine the changes in the motor cortex due to repetitive electrical stimulation and cutaneous anesthesia in lower facial region.
A total of 11 subjects participated in the study of repetitive electrical stimulation, and 10 other subjects in the study of lower facial anesthesia. Facial nerve root and face associated cortical MEPs by transcranial magnetic stimulation (eight-shaped coil) were recorded from perioral muscles pre- and post- electrical stimulation and lower facial anesthesia. Cheek near to the corner of the mouth was transcutaneously stimulated by bipolar surface electrode giving repetitive electrical shocks at 5 Hz. Five percent lidocain/prilocain local anesthetic cream was applied to left or right lip-cheek region.
There was no significant change in perioral MEP responses after 10-30 min of 5 Hz electrical stimulation. We found a significant increase of amplitude in cortical MEP recordings during lower facial anesthesia especially in cases of cortical magnetic stimulations ipsilateral and contralateral to the anaesthetized side and in perioral recordings contralateral to the anaesthetized side.
The present study demonstrates that topical anesthesia to the lower facial region leads to cortical modulation and fast plastic changes in both hemispheres that are directed to the normal side.
确定因重复电刺激和下面部区域皮肤麻醉导致的运动皮层变化。
共有11名受试者参与重复电刺激研究，另有10名受试者参与下面部麻醉研究。在电刺激和下面部麻醉前后，通过经颅磁刺激（八字形线圈）记录面神经根部和面部相关皮层运动诱发电位（MEP），记录口周肌肉的情况。用双极表面电极经皮刺激靠近嘴角的脸颊，以5Hz的频率给予重复电刺激。将5%利多卡因/丙胺卡因局部麻醉乳膏涂抹于左或右唇颊区域。
5Hz电刺激10 - 30分钟后，口周MEP反应无显著变化。我们发现下面部麻醉期间皮层MEP记录的幅度显著增加，尤其是在麻醉侧同侧和对侧的皮层磁刺激以及麻醉侧对侧的口周记录中。
本研究表明，下面部区域的局部麻醉会导致双侧半球向正常侧的皮层调制和快速可塑性变化。
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