Zhang Yongli, Chen Shugeng, Ruan Yinglu, Lin Jiaying, Li Chengdong, Li Chong, Xu Shuo, Yan Zhijie, Liu Xiangyun, Miao Peng, Jia Jie
School of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.
Brain Sci. 2022 Sep 21;12(10):1271. doi: 10.3390/brainsci12101271.
Facial paralysis (FP) is a common symptom after stroke, which influences the quality of life and prognosis of patients. Recently, peripheral magnetic stimulation (PMS) shows potential effects on peripheral and central nervous system damage. However, the effect of PMS on FP after stroke is still unclear.
In this study, we applied PMS on the facial nerve of nine stroke patients with FP. At the same time, laser speckle contrast imaging (LSCI) was used to explore the facial skin blood flow (SkBF) in 19 healthy subjects and nine stroke patients with FP before and after the PMS intervention. The whole face was divided into 14 regions to compare the SkBF in different sub-areas.
In baseline SkBF, we found that there were no significant differences in the SkBF between the left and right faces in the healthy subjects. However, there was a significant difference in the SkBF between the affected and unaffected faces in Region 7 (Chin area, = 0.046). In the following five minutes after the PMS intervention (Pre_0-5 min), the SkBF increased in Region 5 ( = 0.014) and Region 7 ( = 0.046) and there was an increasing trend in Region 3 ( = 0.088) and Region 6 ( = 0.069). In the five to ten minutes after the intervention (Post_6-10 min), the SkBF increased in Region 5 ( = 0.009), Region 6 ( = 0.021) and Region 7 ( = 0.023) and there was an increasing trend in Region 3 ( = 0.080) and left and right whole face ( = 0.051).
These pilot results indicate that PMS intervention could increase facial skin blood flow in stroke patients with FP. A further randomized controlled trial can be performed to explore its possible clinical efficacy.
面瘫是中风后的常见症状，会影响患者的生活质量和预后。近年来，外周磁刺激（PMS）对周围和中枢神经系统损伤显示出潜在作用。然而，PMS对中风后面瘫的影响仍不明确。
在本研究中，我们对9例中风后面瘫患者的面神经施加PMS。同时，采用激光散斑对比成像（LSCI）在PMS干预前后对19名健康受试者和9例中风后面瘫患者的面部皮肤血流（SkBF）进行探测。将整个面部划分为14个区域，以比较不同子区域的SkBF。
在基线SkBF方面，我们发现健康受试者左右面部的SkBF无显著差异。然而，在区域7（下巴区域，P = 0.046），患侧与未患侧面部的SkBF存在显著差异。在PMS干预后的接下来5分钟内（Pre_0 - 5分钟），区域5（P = 0.014）和区域7（P = 0.046）的SkBF增加，区域3（P = 0.088）和区域6（P = 0.069）有增加趋势。在干预后的5至10分钟内（Post_6 - 10分钟），区域5（P = 0.009）、区域6（P = 0.021）和区域7（P = 0.023）的SkBF增加，区域3（P = 0.080）以及左右整个面部（P = 0.051）有增加趋势。
这些初步结果表明，PMS干预可增加中风后面瘫患者的面部皮肤血流。可进一步开展随机对照试验以探索其可能的临床疗效。
