使用对氯苯胺酸和2,3-二氯-5,6-二氰基-1,4-苯醌测定市售剂型中盐酸胺碘酮的经验证的分光光度法。

Validated spectrophotometric methods for the determination of amiodarone hydrochloride in commercial dosage forms using p-chloranilic acid and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone.

作者信息

Rahman Nafisur, Khan Nadeem Ahmad, Azmi Syed Najmul Hejaz

机构信息

Department of Chemistry, Aligarh Muslim University, Aligarh-202002 UP, India.

出版信息

Anal Sci. 2004 Aug;20(8):1231-5. doi: 10.2116/analsci.20.1231.

DOI:10.2116/analsci.20.1231

PMID:15352517

Abstract

Two simple, sensitive and economical spectrophotometric methods have been developed for the determination of amiodarone hydrochloride in pure form and commercial dosage form. These methods (A and B) are based on the reaction of amiodarone base as n-electron donor with p-chloranilic acid and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as pi-acceptors to give highly colored complex species which absorb maximally at 535 and 570 nm, respectively. Beer's law is obeyed in the concentration ranges 10.0 - 360.0 and 2.0 - 65.0 microg ml(-1) for methods A and B, respectively. Application of the proposed methods to commercial pharmaceutical tablets are presented.

摘要

已开发出两种简单、灵敏且经济的分光光度法，用于测定纯品和市售剂型中的盐酸胺碘酮。这些方法（方法A和方法B）基于胺碘酮碱作为n电子供体与对氯苯醌酸和2,3 - 二氯 - 5,6 - 二氰基 - 1,4 - 苯醌（DDQ）作为π受体反应，生成分别在535和570 nm处有最大吸收的高显色络合物。方法A和方法B分别在10.0 - 360.0和2.0 - 65.0 μg ml⁻¹的浓度范围内符合比尔定律。还介绍了所提出方法在市售药片中的应用。