Abdellatef H E
Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt.
J Pharm Biomed Anal. 1998 Sep;17(8):1267-71. doi: 10.1016/s0731-7085(97)00254-9.
Simple, rapid, accurate and sensitive spectrophotometric methods are described for the determination of perindopril. The methods are based on the reaction of this drug as n-electron donor with 2,3-dichloro-5,6-dicyano-p-benzoquinone(DDQ)-7,7,8,8- tetracyanoquinodimethane (TCNQ), tetracyanoethylene (TCNE), chloranil (CL) and p-chloranilic acid (p-CA) as pi-acceptors to give highly coloured complex species. The coloured products are measured spectrophotometrically at 588, 843, 419, 550 and 520 nm for DDQ, TCNQ, TCNE, CL and p-CA, respectively, optimization of different experimental conditions is described. Beer's law is obeyed in the range of 20-200 micrograms ml-1 and colours were produced in non-aqueous media and were stable for at least 1 h. Application of the suggested methods to perindopril tablets are presented.
描述了用于测定培哚普利的简单、快速、准确且灵敏的分光光度法。这些方法基于该药物作为n电子供体与作为π受体的2,3 - 二氯 - 5,6 - 二氰基对苯醌（DDQ）、7,7,8,8 - 四氰基对苯二醌二甲烷（TCNQ）、四氰基乙烯（TCNE）、四氯苯醌（CL）和对氯苯醌酸（p - CA）反应，生成颜色很深的络合物。分别在588、843、4,19、550和520 nm处对DDQ、TCNQ、TCNE、CL和p - CA的有色产物进行分光光度测量，描述了不同实验条件的优化。在20 - 200微克/毫升范围内符合比尔定律，颜色在非水介质中产生且至少稳定1小时。介绍了所建议方法在培哚普利片剂中的应用。
