二维矩阵片剂中分散药物释放的建模。

Modeling of dispersed-drug release from two-dimensional matrix tablets.

作者信息

Zhou Y, Chu J S, Zhou T, Wu X Y

机构信息

AP-CAD Inc., Toronto, Ontario, Canada M2N 3X2.

出版信息

Biomaterials. 2005 Mar;26(8):945-52. doi: 10.1016/j.biomaterials.2004.03.034.

DOI:10.1016/j.biomaterials.2004.03.034

PMID:15353206

Abstract

A mathematical model was developed and analytical solutions were obtained for dispersed-drug release from two-dimensional matrix tablets in a perfect sink. This model can be used to describe kinetics of solute release from matrices with isotropic or anisotropic properties. Moving boundaries of dispersed-drug in both radial and axial directions and release kinetics were predicted by the model. Various factors influencing release kinetics were analyzed including the ratio of initial solute loading (C0) to solute solubility (Cs), the anisotropy of the matrix and the aspect ratio of tablet radius to the half-thickness. The model is also applicable to 1-D planar or 1-D cylindrical geometries when R/H is larger than 100 or smaller than 0.01.

摘要

建立了一个数学模型，并得到了在完美汇条件下二维矩阵片剂中分散药物释放的解析解。该模型可用于描述具有各向同性或各向异性性质的基质中溶质释放的动力学。该模型预测了分散药物在径向和轴向上的移动边界以及释放动力学。分析了影响释放动力学的各种因素，包括初始溶质负载量（C0）与溶质溶解度（Cs）的比值、基质的各向异性以及片剂半径与半厚度的纵横比。当R/H大于100或小于0.01时，该模型也适用于一维平面或一维圆柱几何形状。