State Key Laboratory of Material Processing and Die & Mould Technology, Department of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, People's Republic of China.
J Mater Sci Mater Med. 2011 Jul;22(7):1773-81. doi: 10.1007/s10856-011-4347-y. Epub 2011 May 21.
As a novel copper-containing intrauterine device (IUD), the prospective life-span of the copper/low-density-polyethylene (Cu/LDPE) nanocomposite IUD is very important for the future clinical use and should be given in advance. Here a novel approach, cupric ions accelerated release in diluted nitric acid solution and cupric ions concentration release in various volume of simulated uterine solution (SUS), is reported to verify the type of cupric ions release model of the cylindrical matrix-type nanocomposite IUD, and to obtain the minimal cupric ions release rate that need to ensure contraceptive efficacy and the thickness of copper particles exhausted layer of the cylindrical matrix-type nanocomposite IUD within two difficult immersion durations in experimental volume of SUS, respectively. Using these results, the prospective life-span of the cylindrical matrix-type nanocomposite IUD can be obtained. For instance, the prospective life-span of the novel γ-shape nanocomposite IUD with 25 wt% of copper nanoparticles and 2 mm of diameter and a total weight of 285 mg can be given in advance and it is about 5 years in the future clinical use.
作为一种新型的含铜宫内节育器（IUD），铜/低密度聚乙烯（Cu/LDPE）纳米复合材料 IUD 的预期寿命对于未来的临床应用非常重要，应该提前给出。在这里，我们报道了一种新的方法，即铜离子在稀释硝酸溶液中的加速释放和铜离子在不同体积模拟子宫液（SUS）中的浓度释放，以验证圆柱形基质型纳米复合材料 IUD 的铜离子释放模型类型，并获得最小的铜离子释放率，以确保避孕效果和圆柱形基质型纳米复合材料 IUD 的铜颗粒耗尽层的厚度在 SUS 的两个困难浸没时间内，分别。利用这些结果，可以获得圆柱形基质型纳米复合材料 IUD 的预期寿命。例如，新型γ形状纳米复合材料 IUD 的预期寿命可以提前给出，该 IUD 含有 25wt%的铜纳米颗粒，直径为 2 毫米，总重量为 285 毫克，预计在未来 5 年内将在临床应用。
