Lee Deok-jae, Han Chi Young, Park Sung Ho, Kim Jong Kyung
Department of Nuclear Engineering, Hanyang University, 17 Haengdang, Seongdong, Seoul 133-791, Korea.
Radiat Prot Dosimetry. 2004;110(1-4):655-60. doi: 10.1093/rpd/nch107.
The beam shaping assembly design has been investigated in order to improve the epithermal neutron beam for accelerator-based boron neutron capture therapy in intensity and quality, and dosimetric evaluation for the beams has been performed using both mathematical and voxel head phantoms with MCNP runs. The neutron source was assumed to be produced from a conventional 2.5 MeV proton accelerator with a thick (7)Li target. The results indicate that it is possible to enhance epithermal neutron flux remarkably as well as to embody a good spectrum shaping to epithermal neutrons only with the proper combination of moderator and reflector. It is also found that a larger number of thermal neutrons can reach deeply into the brain and, therefore, can reduce considerably the treatment time for brain tumours. Consequently, the epithermal neutron beams designed in this study can treat more effectively deep-seated brain tumours.
为了提高基于加速器的硼中子俘获疗法中超热中子束的强度和质量,对束流整形组件设计进行了研究,并使用数学模型和体素头部模型通过蒙特卡罗中子输运程序(MCNP)运行对束流进行了剂量学评估。假设中子源由配备厚(7)锂靶的传统2.5兆电子伏质子加速器产生。结果表明,仅通过慢化剂和反射器的适当组合,就有可能显著提高超热中子通量,并实现对超热中子良好的能谱整形。还发现大量热中子可以深入大脑,因此可以大幅减少脑肿瘤的治疗时间。因此,本研究设计的超热中子束可以更有效地治疗深部脑肿瘤。