[KatG基因Ser315Thr突变作为新西伯利亚和克麦罗沃地区分离出的结核分枝杆菌对异烟肼耐药的主要原因]
[KatG Ser3 15Thr mutation as the main reason of isoniazid resistance in Mycobacterium tuberculosis isolated in the Novosibirsk and Kemerovo Regions].
作者信息
Voronina E N, Vikhrova M A, Khrapov E A, Kinsht V N, Norkina O V, Gorbunova E V, Shabaldin A V, Glushkov A N, Krasnov V A, Filipenko M L
出版信息
Mol Gen Mikrobiol Virusol. 2004(3):8-11.
KatG Ser3 15Thr mutation is one of the main reasons of resistance to isoniazid in Mycobacterium tuberculosis isolates. The frequency rate of the above mutation among isoniazid-resistant isolates made 94% in Novosibirsk Region and 93% in Kemerovo Region. The use of PCR-restriction fragment length polymorphism (PCR-RFLP) can be regarded as an adequate method for rapid screening of isoniazid resistance in Mycobacterium tuberculosis isolated in the West-Siberian Region.
KatG基因Ser315Thr突变是结核分枝杆菌分离株对异烟肼耐药的主要原因之一。上述突变在新西伯利亚地区耐异烟肼分离株中的发生率为94%，在克麦罗沃地区为93%。采用聚合酶链反应-限制性片段长度多态性分析（PCR-RFLP）可作为快速筛查西西伯利亚地区分离的结核分枝杆菌对异烟肼耐药性的一种适用方法。
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