van den Bos R, Charria Ortiz G A, Cools A R
Psychoneuropharmacological Research Unit, Catholic University Nijmegen, Netherlands.
Behav Brain Res. 1992 Jun 8;48(2):165-70. doi: 10.1016/s0166-4328(05)80153-6.
The present study explores the behavioural effects of intra-accumbens injections of D-2-amino-7-phosphonoheptanoic acid (AP-7), a selective competitive N-methyl-D-aspartate (NMDA) receptor antagonist, using a swimming test procedure, in which rats were forced to swim for 6 min. The behaviour of the rats was analysed in terms of cue-directed (CDBs) and non-cue-directed behaviours (NCDBs). AP-7 (100-500 ng/0.5 microliter) dose-dependently enhanced the number of switches to CDBs, without affecting the number of switches to NCDBs. Further analysis of the data showed that the number of switches between CDBs was enhanced, while no effect was found on the number of switches from NCDBs to CDBs, from CDBs to NCDBs or between NCDBs. These data suggest that the NMDA-receptor in the nucleus accumbens is involved in the ability to switch between cue-directed behaviours.
本研究采用游泳测试程序，探讨伏隔核内注射选择性竞争性N-甲基-D-天冬氨酸（NMDA）受体拮抗剂D-2-氨基-7-磷酸庚酸（AP-7）的行为效应，在此测试程序中，大鼠被迫游泳6分钟。根据线索导向行为（CDB）和非线索导向行为（NCDB）对大鼠的行为进行分析。AP-7（100 - 500纳克/0.5微升）剂量依赖性地增加了向CDB转换的次数，而不影响向NCDB转换的次数。对数据的进一步分析表明，CDB之间的转换次数增加，而从NCDB到CDB、从CDB到NCDB或NCDB之间的转换次数未受影响。这些数据表明，伏隔核中的NMDA受体参与了线索导向行为之间的转换能力。
