Identification of a novel HLA-DPB1 allele--DPB1*0102.

In this report, we describe the identification of a novel HLA-DPB1 allele, DPB10102, which was first found in a 27-year-old woman and was later detected again in another person, from the Han population of China. According to the nucleotide alignment, DPB10102 was the most similar to DPB10202, with only one nucleotide substitution from A to G at position 192 among three closely related alleles--DPB10202, DPB12401 and DPB10501. This substitution was a non-synonymous one, which caused a change of amino acid from E to K at codon 69 of DP beta-chain in the mature protein.