Mitsch Andreas, Wissner Pia, Böhm Markus, Silber Katrin, Klebe Gerhard, Sattler Isabel, Schlitzer Martin
Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Germany.
Arch Pharm (Weinheim). 2004 Sep;337(9):493-501. doi: 10.1002/ardp.200400871.
We recently described two novel aryl binding sites of farnesyltransferase. In this study, the cinnamoyl residue was designed as an appropriate substituent for our benzophenone-based AAX-peptidomimetic compound capable of occupying the far aryl binding site.
我们最近描述了法尼基转移酶的两个新型芳基结合位点。在本研究中,肉桂酰残基被设计为我们基于二苯甲酮的AAX肽模拟化合物的合适取代基,该化合物能够占据远芳基结合位点。