Mitsch Andreas, Bergemann Silke, Gust Ronald, Sattler Isabel, Schlitzer Martin
Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marburg, Germany.
Arch Pharm (Weinheim). 2003 Jul;336(4-5):242-50. doi: 10.1002/ardp.200300758.
Some 5-acylaminoacylamino-benzophenone derivatives were designed as bisubstrate analogue farnesyltransferase inhibitors. These compounds turned out to be only weakly active against farnesyltransferase, but displayed an antiproliferative effect rendering them suitable for further development as a novel type of cytostatic agents.
一些5-酰基氨基酰基氨基二苯甲酮衍生物被设计为双底物类似物法尼基转移酶抑制剂。结果发现这些化合物对法尼基转移酶的活性较弱，但具有抗增殖作用，使其适合作为新型细胞抑制剂进一步开发。
