兽用抗寄生虫药物研发的不断变化的格局。

The changing landscape of antiparasitic drug discovery for veterinary medicine.

作者信息

Geary Timothy G, Conder George A, Bishop Bernard

出版信息

Trends Parasitol. 2004 Oct;20(10):449-55. doi: 10.1016/j.pt.2004.08.003.

DOI:10.1016/j.pt.2004.08.003

Abstract

Changes in economic imperatives in the pharmaceutical industry have led to a wave of consolidation, which has had the unintended side effect of shrinking the resource devoted to antiparasitic drug discovery in animal health companies. Scientific changes have altered the way in which drugs could be discovered in the future. New science and business models will need to be implemented to address the demand for innovative antiparasitic drugs in veterinary medicine. Novel drugs are needed to combat drug resistance and for currently non-addressed problems. At the center of the future for this field, however, lies the need for more support into the basic research on the biology of parasites.

摘要

制药行业经济需求的变化引发了一轮整合浪潮，这产生了意想不到的副作用，即动物保健公司用于抗寄生虫药物研发的资源减少。科学变革改变了未来药物研发的方式。需要实施新的科学和商业模式来满足兽医学中对创新抗寄生虫药物的需求。需要新型药物来对抗耐药性以及解决目前尚未解决的问题。然而，该领域未来的核心在于需要更多地支持寄生虫生物学的基础研究。