卡马西平在体外可增强大脑中犬尿喹啉酸的生成。

Carbamazepine enhances brain production of kynurenic acid in vitro.

作者信息

Kocki Tomasz, Kocki Janusz, Wielosz Marian, Turski Waldemar A, Urbanska Ewa M

机构信息

Department of Pharmacology and Toxicology, Skubiszewski Medical University, Jaczewskiego 8, 20-090 Lublin, Poland.

出版信息

Eur J Pharmacol. 2004 Sep 13;498(1-3):325-6. doi: 10.1016/j.ejphar.2004.07.088.

DOI:10.1016/j.ejphar.2004.07.088

PMID:15364012

Abstract

Disturbed formation of kynurenic acid, an endogenous antagonist of glutamate ionotropic receptors, might contribute to the pathogenesis of seizures. Here, the effect of anticonvulsant drug, carbamazepine on the production of kynurenic acid was studied. Carbamazepine (0.5-3 mM) enhanced kynurenic acid synthesis in rat cortical slices and also increased the activity of kynurenine aminotransferase (KAT) I at 0.1-3.0 mM concentration. Thus, anticonvulsant drugs, such as carbamazepine, might act partially via stimulation of kynurenic acid production.

摘要

犬尿喹啉酸作为离子型谷氨酸受体的内源性拮抗剂，其生成紊乱可能与癫痫发作的发病机制有关。在此，研究了抗惊厥药物卡马西平对犬尿喹啉酸生成的影响。卡马西平（0.5 - 3 mM）可增强大鼠皮质切片中犬尿喹啉酸的合成，并且在0.1 - 3.0 mM浓度时还可提高犬尿氨酸转氨酶（KAT）I的活性。因此，抗惊厥药物，如卡马西平，可能部分通过刺激犬尿喹啉酸的生成而起作用。