Crusio Wim E
Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA.
Biol Psychiatry. 2004 Sep 15;56(6):381-5. doi: 10.1016/j.biopsych.2003.12.026.
Mice carrying engineered genetic modifications have become an indispensable tool in the study of gene functioning. The interpretation of results obtained with targeted mutants is not completely straightforward, however, because of genetic complications due to linkage and epistasis. Effects of closely linked genes flanking the targeted locus might sometimes be responsible for phenotypic changes ascribed to the null mutation. The effects of the latter might also be modified by the general genetic background. This review presents some examples and discusses some simple strategies to deal with these complications.
携带基因工程改造的小鼠已成为基因功能研究中不可或缺的工具。然而，由于连锁和上位性导致的遗传复杂性，对靶向突变体所获结果的解读并非完全直接明了。位于靶向基因座两侧的紧密连锁基因的效应有时可能是归因于无效突变的表型变化的原因。后者的效应也可能受到一般遗传背景的影响。本综述给出了一些例子，并讨论了应对这些复杂性的一些简单策略。
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