Chemoreduction for retinoblastoma. Analysis of tumor control and risks for recurrence in 457 tumors.

PURPOSE

To evaluate retinoblastoma control following chemoreduction.

DESIGN

Interventional case series.

METHODS

Prospective.

SETTING

Single center trial.

PATIENT POPULATION

457 retinoblastomas in 193 eyes of 125 patients. Nonrandomized, noncomparative study.

INTERVENTION

All patients received intravenous vincristine, etoposide, and carboplatin,. The tumors were managed with chemoreduction alone (group W) or chemoreduction combined with thermotherapy (group X), cryotherapy (group Y), or both thermotherapy and cryotherapy (group Z).

MAIN OUTCOME MEASURE

Tumor recurrence in each treatment group.

RESULTS

Of 457 retinoblastomas, 63 (14%) were in group W, 256 (56%) in group X, 127 (28%) in group Y, and 11 (2%) in group Z. The tumor was located in the macula in 33 (52%) of group W, 109 (43%) of group X, 3 (2%) of group Y, and 9 (1%) of group Z. The mean tumor thickness at initial examination was 7 mm for group W, 4 mm for group X, 2 mm for group Y, and 3 mm for group Z. Using Kaplan-Meier estimates, recurrence of the individual retinoblastoma at 7 years was found in 45% of group W and 18% for combined groups X, Y, and Z. Risk factors predictive of tumor recurrence by multivariate analysis included macular tumor location for all groups and additionally female gender for group W and increasing tumor thickness for groups X, Y, and Z.

CONCLUSIONS

Chemoreduction alone or combined with cryotherapy or thermotherapy is effective for treatment of retinoblastoma, but tumor recurrence rate is highest for those located in the macula and those with greater thickness.