Kohler Lidiane Meire, Monteiro Paulo César Fialho, Hahn Rosane Christine, Hamdan Júnia Soares
Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31270-901 Belo Horizonte, Minas Gerais, Brazil.
J Clin Microbiol. 2004 Sep;42(9):4319-20. doi: 10.1128/JCM.42.9.4319-4320.2004.
Thirty isolates of the yeast form of Sporothrix schenckii were evaluated for in vitro susceptibility to itraconazole and terbinafine by the recommended NCCLS modified technique (M27-A2). The MICs of itraconazole obtained oscillated between 0.062 and 4.0 microg/ml, and those of terbinafine oscillated between 0.007 and 0.50 microg/ml; therefore, terbinafine showed greater in vitro activity.
采用美国国家临床实验室标准委员会(NCCLS)推荐的改良技术(M27 - A2),对30株申克孢子丝菌酵母型菌株进行了体外对伊曲康唑和特比萘芬的敏感性评估。伊曲康唑的最低抑菌浓度(MIC)在0.062至4.0微克/毫升之间波动,特比萘芬的MIC在0.007至0.50微克/毫升之间波动;因此,特比萘芬在体外表现出更强的活性。