头颈部先天性病变的硬化疗法。
Sclerotherapy for congenital lesions in the head and neck.
作者信息
Kim Kwang Hyun, Sung Myung-Whun, Roh Jong-Lyel, Han Moon Hee
机构信息
Department of Otolaryngology-Head and Neck Surgery, Cancer Research Institute, Seoul, Korea.
出版信息
Otolaryngol Head Neck Surg. 2004 Sep;131(3):307-16. doi: 10.1016/j.otohns.2004.02.018.
OBJECTIVES
This study retrospectively reviews the results of sclerotherapy using several sclerosants for congenital lesions of the head and neck.
METHODS AND PATIENTS
Between May 1990 and May 2002, patients with lymphatic malformations were treated by sclerotherapy; 10 with bleomycin, and 25 with OK-432. OK-432 sclerotherapy was also applied in 9 patients with plunging ranula and in 1 patient with branchial anomaly. Percutaneous sclerotherapy with ethanolamine oleate was used in 29 patients with venous malformations, and 28 patients with pyriform sinus fistula were treated by trichloroacetic acid chemocauterization.
RESULTS
Overall, two thirds of patients with these lesions showed marked to complete response. One case of mortality occurred in the bleomycin sclerotherapy group. However, no major complications by other sclerosants were found. In lymphatic malformations, history of excision before sclerotherapy was a poor prognostic factor.
CONCLUSION
Sclerotherapy using these sclerosants is a safe and effective primary treatment for congenital lesions in the head and neck.
目的
本研究回顾性分析使用多种硬化剂对头颈部先天性病变进行硬化治疗的结果。
方法与患者
1990年5月至2002年5月期间，对淋巴管畸形患者进行硬化治疗；10例使用博来霉素，25例使用OK-432。9例舌下囊肿患者和1例鳃裂畸形患者也接受了OK-432硬化治疗。29例静脉畸形患者采用油酸乙醇胺经皮硬化治疗，28例梨状窦瘘患者采用三氯乙酸化学烧灼治疗。
结果
总体而言，这些病变患者中有三分之二显示出明显至完全缓解。博来霉素硬化治疗组发生1例死亡。然而，未发现其他硬化剂引起的严重并发症。在淋巴管畸形中，硬化治疗前的切除史是一个不良预后因素。
结论
使用这些硬化剂进行硬化治疗是头颈部先天性病变安全有效的主要治疗方法。
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