Artik S, Gleichmann E, Ruzicka T
Institut für umweltmedizinische Forschung an der Heinrich-Heine-Universität Düsseldorf gGmbH, Abteilung für Allergologie und Immunologie, Universitätshautklinik, Heinrich-Heine-Universität Düsseldorf
Hautarzt. 2004 Nov;55(11):1052-9. doi: 10.1007/s00105-004-0815-3.
Nickel is the most common contact allergen in humans. Until recently, many questions concerning tolerance mechanisms to nickel were unresolved. Besides human ex vivo, intervention and observation studies, the establishment of a reproducible mouse model has contributed to the analysis of these mechanisms. A more detailed understanding of the pathogenesis of nickel allergy and tolerance towards nickel by investigations in an animal model and in human studies is a prerequisite for developing specific prevention and therapy of nickel allergy. With this article, we provide a review of the investigations concerning nickel allergy and give perspectives towards oral tolerance induction to nickel in the animal model and in humans.
镍是人类最常见的接触性过敏原。直到最近，许多关于镍耐受机制的问题仍未得到解决。除了人体离体、干预和观察研究外，可重复的小鼠模型的建立有助于对这些机制进行分析。通过在动物模型和人体研究中的调查，更详细地了解镍过敏的发病机制和对镍的耐受性，是开发镍过敏特异性预防和治疗方法的先决条件。在本文中，我们对有关镍过敏的研究进行了综述，并展望了在动物模型和人体中诱导对镍的口服耐受性。
