Kobielak Agnieszka, Fuchs Elaine
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, Rockefeller University, 1230 York Avenue, Box 300, New York, New York 10021, USA.
Nat Rev Mol Cell Biol. 2004 Aug;5(8):614-25. doi: 10.1038/nrm1433.
Alpha-catenin has often been considered to be a non-regulatory intercellular adhesion protein, in contrast to beta-catenin, which has well-documented dual roles in cell-cell adhesion and signal transduction. Recently, however, alpha-catenin has been found to be important not only in connecting the E-cadherin-beta-catenin complex to the actin cytoskeleton, but also in coordinating actin dynamics and inversely correlating cell adhesion with proliferation. As the number of alpha-catenin-interacting partners increases, intriguing new connections imply even more complex regulatory functions for this protein.
与β-连环蛋白不同，α-连环蛋白通常被认为是一种非调节性细胞间粘附蛋白，β-连环蛋白在细胞间粘附和信号转导中具有充分记录的双重作用。然而，最近发现α-连环蛋白不仅在将E-钙粘蛋白-β-连环蛋白复合物连接到肌动蛋白细胞骨架方面很重要，而且在协调肌动蛋白动力学以及使细胞粘附与增殖呈负相关方面也很重要。随着与α-连环蛋白相互作用的伙伴数量增加，有趣的新联系意味着该蛋白具有更复杂的调节功能。
